Concurrent Session IV B: Platelet Production, Signaling and Function Moderators:

2:45 pm

Platelets: The Crossroad of Immunity and Thrombosis

Milka Koupenova, PhD, University of Massachusetts Medical School, Worcester, Massachusetts

Oral Abstract Presentations

3:05 pm

**The Intrinsic Tenase Regulates Platelet Activation During Hemostasis in vivo (163)**

Maurizio Tomaiuolo, Tanya T Marar, Univ of Pennsylvania, Philadelphia, PA; Chelsea N. Matzko, Univ of Pennsylvania, Phialdelphia, PA; Timothy J Stalker, Univ of Pennsylvania, Philadelphia, PA

3:15 pm

Single-Cell Rna-seq of Megakaryocytes Identifies Novel Pathways Involved in the Mitochondrial Dysfunction of Tnf- Driven Platelet Hyperreactivity (164)

Pavel Davizon-Castillo, Andrew Thorburn, Univ of Colorado, Denver, CO

3:25 pm

A Hypo-reactive Protease Activated Receptor 4 (PAR4) Variant is Associated With a Reduced Risk of Venous Thromboembolism (165)

Xu Han, Elizabeth Knauss, Case Western Reserve Univ, Cleveland, OH; INVENT Consortium; Lalitha Nayak, Cleveland, OH; Marvin T Nieman, Case Western Reserve Univ, Cleveland, OH

3:35 pm

Pirfenidone Attenuates Cardiac Fibrosis in a High Shear Ascending Aortic Constriction Mouse Model: Role of Shear-induced Platelet TGF-β1 Activation (166)

Sandeep Subrahmanian, Sean Woolington, Sandra Gostynska, Jasimuddin Ahamed, Oklahoma Medical Res Foundatio, Oklahoma City, OK

3:45 pm

Benefit-Risk Profile of Dual Antiplatelet Therapy Continuation Beyond 1 Year After Pci in Patients With Moderately Increased Risk Features of Ischemic Events as Endorsed by 2019 ESC Chronic Coronary Syndromes Guidelines (167)

Haoyu Wang, Kefei Dou, Runlin Gao, Dept of Cardiology, Coronary Heart Disease Ctr, Fuwai Hosp, Natl Ctr for Cardiovascular Diseases, Chinese Acad of Medical Sciences & Peking Union Medical Coll, Beijing, China; Ajay J Kirtane, NewYork-Presbyterian Hosp/Columbia Univ Medical Ctr, New York, NY