Vascular Discovery 2020 Invited Lecturer Louisa Iruela-Arispe, PhD, describes her recent work exploring the molecular mechanisms contributing to recovery after cardiovascular injury.
Vascular Discovery at Your Fingertips
Vascular Discovery: From Genes to Medicine Scientific Sessions 2020 took place May 5-7.

2020 ePosters and moderated ePosters are open access and available to all. Click on the “Access ePosters” button on the right side of this page.

Key Dates for Vascular Discovery 2021

Nov. 3, 2020    

Jan. 6, 2021      

Jan. 19, 2021     

Mar. 31, 2021 

Apr. 28, 2021 

Apr. 29, 2021 

Abstract and award submissions open for ATVB and VRIC

Online registration opens

Abstract and award submissions close

Early registration deadline

Advance registration deadline

Standard registration rates apply 

Science News
Inhibition of MicroRNA-33 Reprograms the Transcriptional Landscape and Kinetic Processes of Immune Cells to Promote Atherosclerotic Plaque Regression

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MicroRNA-33 (miR-33) is a key regulator of cholesterol and fatty acid metabolism genes. Inhibition of miR-33 increases plasma HDL and promotes atherosclerosis regression, in part, by enhancing reverse cholesterol transport. Additionally, miR-33 inhibitors promote resolution of plaque inflammation, independent of effects on cholesterol homeostasis, yet the underlying mechanisms remain poorly described. More From the Authors

Single Cell RNA Sequencing Reveals Heterogeneous Smooth Muscle Cell Phenotype Modulation in Marfan Syndrome Aortic Aneurysm

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Rationale: Aortic root aneurysm can lead to aortic dissection or fatal rupture in Marfan syndrome (MFS) patients. Vascular smooth muscle cells (SMCs) maintain plasticity to switch from contractile to “synthetic” phenotype in response to disease. Paradoxically, aortic tissue from MFS patients shows simultaneous overexpression of both contractile and synthetic genes. More From the Authors

Wnt Signaling Enhances Macrophage Response to IL4/13 and Promotes Resolution of Atherosclerosis

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While significant progress has been made in the ability to slow the progression of atherosclerosis, resolution of atherosclerosis remains elusive. We previously reported that the transcription factor STAT6 is required for resolution of atherosclerosis in mice. The current study investigates relevant pathways upstream of STAT6. More From the Authors

Naturally Occurring Deletion of Lys 107 Does Not Alter Lipid Binding Affinity of Apolipoprotein A-I

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Human apolipoprotein A-I (apoA-I) is the major protein component of high-density lipoproteins (HDLs) that plays a pivotal role in lipoprotein metabolism. The deletion mutant Lys107del (∆K107) is a natural variant of apoA-I (Wt) related to early atherosclerosis and hypertriglyceridemia in carriers. While this mutant has been extensively studied, little information exists on the structural and functional basis for this phenotype. More From the Authors

Vascular Aging Alters Mitophagy to Lead to Galectin 3 Secretion

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Immunity and Inflammation in Vascular Biology MP1  |  Moderated Poster Session 1: Junior Investigator Award for Women Poster Competition 

Aging alters the removal of damaged mitochondria (mitophagy) but how this impacts the vasculature is unclear. Here, we investigated the relationship between inflammatory pathways and mitophagy in vascular aging. More From the Authors

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