Plenary Session IV: Award Competition

Moderators: Coleen A. McNamara, MD, FAHA, University of Virginia, Charlottesville, Virginia Marvin T. Nieman, PhD, FAHA, Case Western Reserve University, Cleveland, Ohio

12:20 pm

Finalists for the Kenneth M. Brinkhous Early Career Investigator Prize in Thrombosis

Targeting Myeloid-Cell Specific Integrin Alpha9Beta1 Inhibits Arterial Thrombosis and Improves Stroke Outcome by Limiting Thrombo-inflammation (150)

Nirav Dhanesha, Manasa Nayak, Manish Jain, Prakash Doddapattar, Univ of Iowa, Iowa City, IA; Girish Bathla, Univ of Iowa Hosp and Cl, Iowa City, IA; Madankumar Ghatge, Univ of Iowa, Iowa city, IA; Steven R Lentz, Anil K Chauhan, Univ of Iowa, Iowa City, IA

12:30 pm

Vein-on-Chip: Microengineered Modeling of Venous Valves, Thrombosis and Therapeutics (151)

Abhishek Jain, Texas AnM Univ, College Station, TX

12:40 pm

Evaluating the Impact of Thrombocytopenia and Platelet Transfusion on Bleeding and Thrombosis in the Setting of Anti-Platelet Therapy (152)

Robert H. Lee, David S Paul, Wolfgang Bergmeier, Univ of North Carolina, Chapel Hill, NC

12:50 pm

A Genome-Wide Screen for Modifiers of Tissue Factor Activity Identifies the Palmitoyltransferase ZDHHC2 as a Negative Regulator of Coagulation Initiation (153)

Sol Schulman, Emale El-Darzi, Calvin Schuster, Natasha Panwar, Beth Israel Deaconess Medical Ctr, Boston, MA; Ariel Feiglin, Harvard Medical Sch, Dept of Biomedical Informatics, Boston, MA; Bruce Furie, Robert C Flaumenhaft, Beth Israel Deaconess Medical Ctr, Boston, MA

1 pm

Finalists for the Irvine H. Page Junior Faculty Research Award

Adipocyte Tribbles1 Regulates Plasma Lipids and Circulating Adiponectin (154)

Elizabeth E Ha, Noel Walsh, Gabriella I Quartuccia, Robert C Bauer, Columbia Univ, New York, NY

1:10 pm

H3K4 Di-methylation Controls Vascular Smooth Muscle Cell Lineage Identity, Contractility, and Participation in Vascular Remodeling (155)

Mingjun Liu, Sidney Mahan, Cristina Espinosa, Univ of Pittsburgh, Pittsburgh, PA; Anh Nguyen, Charlottesville, VA; Scott Hahn, Adam C Straub, Univ of Pittsburgh, Pittsburgh, PA; Kathleen A Martin, Yale Sch of Med, New Haven, CT; Gary K Owens, Univ of Virginia, Charlottesville, VA; Delphine A Gomez, Univ of Pittsburgh, Pittsburgh, PA

1:20 pm

Endothelial Rna-binding Protein Elavl1 (HuR) Regulates Alternative Splicing of Genes Involved in Adaptive Immunity and Increases T Cells in the Atherosclerotic Intima (156)

Sarah-Anne E Nicholas, Jessica A Hensel, Maria M Xu, Amy L Kimble, Antoine Menoret, Brent Heineman, Evan R Jellison, UCONN Health, Farmington, CT; Bo Reese, UCONN, Storrs, CT; Beiyan Zhou, UConn Health Ctr, Farmington, CT; Annabelle Rodriquez-Oquendo, Anthony Vella, Patrick A Murphy, UCONN Health, Farmington, CT

1:30 pm

**A Genome-Wide CRISPR Screen in Primary Macrophages Reveals WDFY3 as a Novel Regulator of Macrophage Efferocytosis in vitro and in vivo (157)**

Jianting Shi, Columbia Univ, New York, NY; Xun Wu, Fang Li, Columbia Univ Medical Ctr, New York, NY; Jiayi Shen, Columbia Univ Irving Medical Ctr, New York, NY; Chenyi Xue, Columbia Univ, New York, NY; Raneem Hamad, Katherine R Croce, Columbia Univ Irving Medical Ctr, New York, NY; Arif Yurdagul, Columbia Univ, New York, NY; Glykeria Karadimou, Gabrielle Paulsson-Berne, Karolinska Instt, Stockholm, Sweden; John G Doench, Broad Inst of MIT and Harvard, Cambridge, MA; Charles Karan, Columbia Univ Irving Medical Ctr, New York, NY; Danish Saleheen, Columbia Univ Irving Medical Ctr, New York, NY, New york, NY; Ira A Tabas, Columbia Univ, New York, NY; Ai Yamamoto, Hanrui Zhang, Columbia Univ Irving Medical Ctr, New York, NY