Mast Cells Are the Trigger of Small Vessel Disease and Diastolic Dysfunction in Diabetic Obese Mice

We used leptin receptor deficient (Leprdb/db) female mice, a recognized model of diastolic dysfunction.

Originally published 11 Feb 2021 | Arteriosclerosis, Thrombosis, and Vascular Biology

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Heart failure with preserved ejection fraction is a major health care issue which has been difficult to manage to date, due to its complex and not well understood pathophysiology. Specifically, if a wealth of literature focuses on heart failure with preserved ejection fraction cardiac component, very little information can be found on its vascular component. Our goal is to unravel the critical role of cardiac small vessel disease in the pathophysiology of diastolic dysfunction.


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