Apr 23rd, 2021

Mast Cells Are the Trigger of Small Vessel Disease and Diastolic Dysfunction in Diabetic Obese Mice

We used leptin receptor deficient (Leprdb/db) female mice, a recognized model of diastolic dysfunction.

Sarah Guimbal, Lauriane Cornuault, Paul Rouault, Pierre-Louis Hollier, Candice Chapouly, Marie-Lise Bats, Julien Imbault, Alain-Pierre Gadeau, Thierry Couffinhal, Marie-Ange Renault
Originally published 11 Feb 2021 | Arteriosclerosis, Thrombosis, and Vascular Biology
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Objective

Heart failure with preserved ejection fraction is a major health care issue which has been difficult to manage to date, due to its complex and not well understood pathophysiology. Specifically, if a wealth of literature focuses on heart failure with preserved ejection fraction cardiac component, very little information can be found on its vascular component. Our goal is to unravel the critical role of cardiac small vessel disease in the pathophysiology of diastolic dysfunction.

Abstract

The complete text of this article can be found at https://www.ahajournals.org/doi/10.1161/ATVBAHA.121.315900.