Nov 19th, 2020

Genome-Wide Polygenic Score, Clinical Risk Factors, and Long-Term Trajectories of Coronary Artery Disease

George Hindy, Krishna G. Aragam, Kenney Ng, Mark Chaffin, Luca A. Lotta, Aris Baras, and Regeneron Genetics Center, Isabel Drake, Marju Orho-Melander, Olle Melander, Sekar Kathiresan, Amit V. Khera
Originally published 22 Sep 2020 | Arteriosclerosis, Thrombosis, and Vascular Biology
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Objective:

To determine the relationship of a genome-wide polygenic score for coronary artery disease (GPSCAD) with lifetime trajectories of CAD risk, directly compare its predictive capacity to traditional risk factors, and assess its interplay with the Pooled Cohort Equations (PCE) clinical risk estimator.


The full text of this article can be found at: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.120.318257