Concurrent Session III A: Therapeutic Targets in Atherosclerosis

Oral Abstract Presentations

11:05 am

Design and Delivery of Microrna Switches to Treat Cardiovascular Diseases (130)

Hana Totary-jain, John Lockhart, Samuel Wickline, Hua Pan, Univ of South Florida, Tampa, FL

11:15 am

Network-Driven Drug Repositioning Unveils a New Anti-Atherosclerotic Effect of an Old Compound (131)

Letizia Amadori, Claudia Calcagno, Peik Sean Chong, Roza Shamailova, Christopher Faries, Icahn Sch of Med Mount Sinai, New York, NY; Ben Readhead, ASU-Banner Neurodegenerative Disease Res Ctr Arizona State Univ, Tempe, AZ; Joel Dudley, Icahn Sch of Med Mount Sinai, New York, NY; Zahi Fayad, BioMedical Engineering and Imaging Inst, Icahn Sch of Med Mount Sinai, New York, NY; Johan Bjorkegren, Chiara Giannarelli, Icahn Sch of Med Mount Sinai, New York, NY

11:25 am

Inhibition of MicroRNA-33 Reprograms the Transcriptional Landscape and Kinetic Processes of Immune Cells to Promote Atherosclerotic Plaque Regression (132)

Milessa Silva Afonso, Monika Sharma, Paul Martin Schlegel, Alireza Khodadadi-Jamayran, Coen van Solingen, Lianne Shanley, Graeme J Koelwyn, Lauren Beckett, Daniel Peled, Karishma Rahman, New York Univ, New York, NY; Mireille Ouimet, Univ of Ottawa Heart Inst, Ottawa, ON, Canada; Edward A Fisher, Kathryn J Moore, New York Univ, New York, NY

11:35 am

Selective Bromodomain Inhibition With the Bromodomain and Extraterminal Domain Inhibitor Apabetalone: Discovery to Phase 3 CVOT Study (133)

Norman C. w Wong, Ewelina Kulikowski, Brooke D Rakai, Michael Sweeney, Resverlogix Corp, Calgary, AB, Canada; Jan O Johansson, Resverlogix Corp, San Francisco, CA; Stephen J Nicholls, Monash Heart, Melbourne, Australia; Kevin A Buhr, Univ of Wisconsin-Madison, Madison, WI; Henry N Ginsberg, Columbia Univ, New York, NY; Peter P Toth, CGH Medical Ctr, Peoria, IL; Gregory G Schwartz, Univ of Colorado, Denver, CO; Kausik K Ray, Imperial Coll London, London, United Kingdom

11:45 am

Immune Checkpoint Inhibitors Aggravate T Cell-mediated Plaque Inflammation in Experimental Atherosclerosis (134)

Kikkie Poels, Amsterdam UMC - Location AMC, Amsterdam, Netherlands; Mandy van Leent, Mount Sinai, New York, NY; Myrthe Reiche, Tsveta Malinova, Stephan Huveneers, Amsterdam UMC - Location AMC, Amsterdam, Netherlands; Menno De Winther, Academic Medical Ctr, Amsterdam, Netherlands; Willem Mulder, Mount Sinai Sch of Med, New York, NY; Esther Lutgens, Amsterdam Univ Medical Ctr, Amsterdam, Netherlands; Tom Seijkens, Amsterdam UMC - Location AMC, Amsterdam, Netherlands