Jun 25th, 2020

Role of PAR1-Egr1 in the Initiation of Thoracic Aortic Aneurysm in Fbln4-Deficient Mice

Using a mouse model of postnatal ascending aortic aneurysms, we have reported that abnormal mechanosensing led to aneurysm formation in Fbln4SMKO with an upregulation of the mechanosensitive transcription factor, Egr.

Seung Jae Shin, Huynh Thuy Hang, Bui Quoc Thang, Tomonari Shimoda, Hiroaki Sakamoto, Motoo Osaka, Yuji Hiramatsu, Yoshito Yamashiro, Hiromi Yanagisawa
Originally published 25 Jun 2020 | Arteriosclerosis, Thrombosis, and Vascular Biology
Getty Images 157674600

Abstract

Objective:

Remodeling of the extracellular matrix plays a vital role in cardiovascular diseases. Using a mouse model of postnatal ascending aortic aneurysms (termed Fbln4SMKO), we have reported that abnormal mechanosensing led to aneurysm formation in Fbln4SMKO with an upregulation of the mechanosensitive transcription factor, Egr1 (Early growth response 1). However, the role of Egr1 and its upstream regulator(s) in the initiation of aneurysm development and their relationship to an aneurysmal microenvironment are unknown.

Full text of this article can be found at: https://www.ahajournals.org/doi/10.1161/ATVBAHA.120.314560