MEF2 Is Essential for Endothelial Homeostasis and the Atheroprotective Gene Expression Program

Originally published 7 Jan 2021 | Arteriosclerosis, Thrombosis, and Vascular Biology

2021 03 22 13 49 56



Atherosclerosis predominantly forms in regions of oscillatory shear stress while regions of laminar shear stress are protected. This protection is partly through the endothelium in laminar flow regions expressing an anti-inflammatory and antithrombotic gene expression program. Several molecular pathways transmitting these distinct flow patterns to the endothelium have been defined. Our objective is to define the role of the MEF2 (myocyte enhancer factor 2) family of transcription factors in promoting an atheroprotective endothelium.

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