Unfolded Protein Response Drives Smooth Muscle Cell Phenotypic Changes With Cholesterol
Vascular smooth muscle cells (SMCs) dedifferentiate and initiate expression of macrophage markers with cholesterol exposure. This phenotypic switching is dependent on the transcription factor Klf4 (Krüppel-like factor 4). We investigated the molecular pathway by which cholesterol induces SMC phenotypic switching.
The complete article can be found at https://www.ahajournals.org/doi/10.1161/ATVBAHA.120.315164.