Neutrophil Extracellular Trap Degradation by Differently Polarized Macrophage Subsets

Originally published 16 Jul 2020 | Arteriosclerosis, Thrombosis, and Vascular Biology

2020 09 17 15 37 01


Macrophages are immune cells, capable to remodel the extracellular matrix, which can harbor extracellular DNA incorporated into neutrophil extracellular traps (NETs). To study the breakdown of NETs we studied the capability of macrophage subsets to degrade these structures in vitro and in vivo in a murine thrombosis model. Furthermore, we analyzed human abdominal aortic aneurysm samples in support of our in vitro and in vivo results.

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