Jul 16th, 2020

Neutrophil Extracellular Trap Degradation by Differently Polarized Macrophage Subsets

Patrick Haider, Julia B. Kral-Pointner, Julia Mayer, Manuela Richter, Christoph Kaun, Christine Brostjan, Wolf Eilenberg, Michael B. Fischer, Walter S. Speidl, Christian Hengstenberg, Kurt Huber, Johann Wojta, Philipp Hohensinner
Originally published 16 Jul 2020 | Arteriosclerosis, Thrombosis, and Vascular Biology
2020 09 17 15 37 01

Objective:

Macrophages are immune cells, capable to remodel the extracellular matrix, which can harbor extracellular DNA incorporated into neutrophil extracellular traps (NETs). To study the breakdown of NETs we studied the capability of macrophage subsets to degrade these structures in vitro and in vivo in a murine thrombosis model. Furthermore, we analyzed human abdominal aortic aneurysm samples in support of our in vitro and in vivo results.

The full text of this article can be found at: https://www.ahajournals.org/journal/doi/10.1161/ATVBAHA.120.314883.